Immunization with Pneumocystis carinii A121–85 antigen activates immune function against P. carinii

Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen.

Mice immunized with recombinant mouse Pneumocystis carinii antigen A12-thioredoxin fusion protein developed an antibody response that recognized P. carinii antigens, as determined by Western blotting and immunofluorescence analysis. Compared to mice immunized with thioredoxin alone, mice immunized with A12-thioredoxin had significantly reduced lung P. carinii burdens after CD4+ T-cell depletion...

Pneumocystis carinii.

Although Giemsa staining has been routinely used for the detection of trophozoites and intracystic bodies in smears of bronchoalveolar lavage fluid (BAL) from patients with Pneumocystis cariniipneumonia, it does not normally stain the cyst wall. For detection ofthe cysts other stains such as toluidine Blue 'O' and methenamine silver must be used as well. Sulphation of smears before staining wit...

HIV impairs alveolar macrophage mannose receptor function against Pneumocystis carinii.

Action of deferoxamine against Pneumocystis carinii.

We found earlier that deferoxamine (DFO), a drug used for treatment of iron overload, is active against a rat model of Pneumocystis carinii pneumonia (PCP). We had assumed a mode of action by deprivation of nutritional iron; however, data here show that DFO penetrates P. carinii, causing irreversible damage, thus indicating a different mode of action. Penetration was demonstrated by showing DFO...

Endemic Pneumocystis Carinii Pneumonia

The entity of interstitial plasma cell pneumonia due to Pneumocystis carinii has received increasing attention during the past 10 years. Extensive studies and reviews concerning this problem, its epidemiology and pathogenesis (Ahvenainen, 1957; Bachmann, 1954; Cahalane, 1962; Jirovec, 1 960a and b; Muller and Vietor, 1957), its clinical course and picture (Berdnikoff, 1959; Dvorak and Jirovec, ...